I don't think you can ever completely transform yourself on film, but if you do your job well, you can make people believe that you're the character you're trying to be.
Changes to parliamentary procedure won't transform the lives of the people whom I represent. Decentralising, devolving decision-making and renewing civil society will.
Even if you're only wearing trainers and a vest, eyeliner will instantly transform you. People always look put-together when their make-up's on and their eyes are popping - just ask Amy Winehouse!
If the U.S. can transform its domestic market for HIV/AIDS drugs, it will certainly transform the world market and make HIV/AIDS drugs more affordable for everyone, everywhere.
A really great actor, in a lucky performance, can transform himself or herself. I've seen actors do that. But often it's a mechanical transformation, which isn't as interesting, and you've got to be careful how you go about something like that, I think.