We may say that a basic substance is one which has a lone pair of electrons which may be used to complete the stable group of another atom, and that an acid is one which can employ a lone pair from another molecule in completing the stable group of one of its own atoms.
Since hydrogen is a constituent of most of our electrolytic solvents, the definition of an acid or base as a substance which gives up or takes up hydrogen ion would be more general than the one we used before, but it would not be universal.
I maintain also that substances, whether material or immaterial, cannot be conceived in their bare essence without any activity, activity being of the essence of substance in general.
The criminalization of marijuana did not prevent marijuana from becoming the most widely used illegal substance in the United States and many other countries. But it did result in extensive costs and negative consequences.
I can see now that a concept or even a feeling makes no sense unless out of our substance we spin around it a web of references, of relationships, of values.