Large companies are not going to disappear. Multinational companies with tens of thousands of employees are not going to disappear. In fact, many of them are getting larger because they can benefit from economies of scale.
'Game of Thrones' is the broadest of narratives. I don't know if anyone in the U.S. has done a story on such a large scale before, both in terms of what George R.R. Martin wrote and what's on the show.
I think scale is about, in a way, the apprehension of proportion, and all the proportions that mean things to us as human beings are related to the body.