People should watch out for three things: avoid a major addiction, don't get so deeply into debt that it controls your life, and don't start a family before you're ready to settle down.
When I cleaned up some 17 odd years ago, I felt terrible for about six months. The only thing that gave me any real relief was strenuous physical activity.
I think people are isolated because of the nature of human consciousness, and they like it when they feel the connection between themselves and someone else.